In this section, you can access to the latest technical information related to the FUTURE project topic.

Multifunctional nanoparticles self-assembled from polyethylenimine-based graft polymers as efficient anticancer drug delivery

Multiple functionalization of nanoparticles has attracted great interest in drug delivery. In this paper, polymeric amphiphiles of polyethylenimine (PEI) conjugated with methoxy poly(ethylene glycol) aldehyde (mPEG-CHO), poly(? caprolactone) aldehyde (PCL-CHO) and pyrene-1-carboxaldehyde (Py-CHO) were synthesized via Schiff’s reaction. The conjugates self-assembled into nanoparticles with pH-sensitivity to load anticancer drug doxorubicin (DOX), further coated with hyaluronic acid (HA) for tumor targeting. The mean size of nanoparticles was about 100nm and the stability of the nanoparticles was well in aqueous solution. The nanoparticles coated with HA showed faster disassembly in acidic solution, resulting in faster drug release in the medium with pH 5.0 compared to uncoated nanoparticles. Moreover, the nanoparticles exhibited an endosomal escape function to accelerate the release of DOX in cancer cells, which led to low IC50s to kill breast cancer cells (4T1) and liver cancer cells (HepG2) in vitro.

» Author: Jianqin Yan, Ting Su, Furong Cheng, Jun Cao, Hai Zhang, Bin He

» Reference: Colloids and Surfaces B: Biointerfaces, Volume 155

» Publication Date: 01/07/2017

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