The ZE21B magnesium alloy, pretreated with hydrofluoric acid and dopamine, has been modified with fucoidan and ACH11 peptide. The resultant modified ZE21B alloy exhibits several biological functions, including the inhibition of hemolysis and fibrinogen adhesion/denaturation, suppression of smooth muscle cell adhesion and proliferation, and promotion of adhesion, proliferation, and spreading of endothelial cells.Magnesium alloy stents show cardiovascular promise due to strength and biodegradability , but   rapid degradation and poor compatibility limit their clinical use.Herein, this study proposes a multilayer coating to enhance the corrosion resistance and biocompatibility of ZE21B alloy in vascular stent applications. The coating combines a MgF2 layer and a PDA layer, further functionalized with fucoidan and ACH11 peptides. Surface analysis indicated that the treated ZE21B alloy displayed a dense chemical conversion layer embedded with active biomolecules. The coated magnesium alloy possessed appropriate roughness, balanced wettability (around 56.1°), and a relatively low self?corrosion current density (about 2.0?×?10?7 A?cm?2). Blood compatibility tests indicated that the hemolysis rate and fibrinogen adsorption/denaturation levels of the coated magnesium alloy were approximately halved compared to untreated magnesium alloy, both meeting the requirements for blood?contact medical devices. Additionally, the synergistic effect of fucoidan and ACH11 peptides significantly promoted endothelial cells (ECs) proliferation and nitric oxide release while inhibiting smooth muscle cells proliferation levels. This selective cellular response created a favorable environment for ECs regeneration. By substantially improving both corrosion resistance and vascular compatibility, this advanced coating system presents a groundbreaking approach to developing next?generation biodegradable stents.

» Author: Yaqing Zhao, Yunwei Gu, Bin Yin, Lan Chen, Lingchuang Bai, Shaokang Guan

» Publication Date: 24/08/2025

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