In this section, you can access to the latest technical information related to the FUTURE project topic.

A Practical and Modular Method for Direct C?H Functionalization of the BODIPY Core via Thianthrenium Salts

A general and modular photochemical method for the direct C?H functionalization of the BODIPY core with versatile thianthrenium salts to prepare diverse aryl? and alkenyl?substituted BODIPY dyes was developed. This mild protocol proceeds with high site?selectivity and functional?group tolerance, and enabled the synthesis of sophisticated disubstituted BODIPY dyes and the late?stage BODIPY modification of complex drug molecules.Direct structural modification of small?molecule fluorophores represents a straightforward and appealing strategy for accessing new fluorescent dyes with desired functionalities. We report herein a general and efficient visible?light?mediated method for the direct C?H functionalization of BODIPY, an important fluorescent chromophore, using readily accessible and bench?stable aryl and alkenylthianthrenium salts. This practical approach operates at room temperature with extraordinary site?selectivity, providing a step?economical means to construct various valuable aryl? and alkenyl?substituted BODIPY dyes. Remarkably, this protocol encompasses a broad substrate scope and excellent functional?group tolerance, and allows for the modular synthesis of sophisticated symmetrical and asymmetrical disubstituted BODIPYs by simply employing different combinations of thianthrenium salts. Moreover, the late?stage BODIPY modification of complex drug molecules further highlights the potential of this novel methodology in the synthesis of fluorophore?drug conjugates.

» Publication Date: 12/07/2024

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