In this section, you can access to the latest technical information related to the FUTURE project topic.

A Bench?stable 8?Aminoquinoline Derived Phosphine?free Manganese (I)?Catalyst for Environmentally Benign C(?)?Alkylation of Oxindoles with Secondary and Primary Alcohols

Herein we report a new air?stable phosphine?free 8?AQ (8?aminoquinoline) based Mn(I) carbonyl complex as the catalyst for the C(?)?alkylation of oxindoles with alcohols. The Mn complex [(8?AQ)Mn(CO)3Br] works effectively as a catalyst for ??alkylation of oxindoles by both secondary as well as primary alcohols. The procedure has been used for the synthesis of pharmaceutically important recently developed oxindoles such as 3?(4?methoxybenzyl)indolin?2?one, 3?(4?(dimethylamino)benzyl)indolin?2?one, 3?(4?(dimethylamino)phenyl)?5?fluoroindolin?2?one and 3?(benzo[d][1,3]dioxol?5?ylmethyl)indolin?2?one, which are found to be effective in preventing specific types of cell death in neurodegenerative disorders. Control experiments have been carried out to investigate the reaction mechanism and the crucial role of metal?ligand cooperation via ?NH2 moiety during catalysis.

» Publication Date: 23/01/2023

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