In this section, you can access to the latest technical information related to the FUTURE project topic.

Palladium?Catalyzed Reductive Double Carbonylation of Nitroarenes with Aryl Halides Using Mo(CO)6 as a Reductant and Carbonyl Source

A novel palladium?catalyzed reductive double carbonylation of nitroarenes with aryl halides for the synthesis of benzoxazin?4?ones has been reported. The key to success was the use of Mo(CO) 6 as a reductant and bench?stable solid carbonyl sources.?Various aryl iodides, bromides, and trifluoromethanesulfonates are suitable reaction partners and produce corresponding benzoxazin?4?one derivatives in moderate to good yields. Preliminary mechanistic studies indicate that nitrosoarene was first generated as the key intermediate through nitro reduction. Remarkably, this method avoids the use of toxic CO gas and is further applied to the late?stage modification of estrone.

» Publication Date: 30/09/2022

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