In this section, you can access to the latest technical information related to the FUTURE project topic.

Ru(II)-modified TiO2 nanoparticles for hypoxia-adaptive photo-immunotherapy of oral squamous cell carcinoma

The alternations in the hypoxic and immune microenvironment are closely related to the therapeutic effect and prognosis of oral squamous cell carcinoma (OSCC). Herein, a new nanocomposite, TiO2@[email protected] is constructed from a ruthenium-based photosensitizer (Ru) modified-TiO2 nanoparticles (NPs) loaded with siRNA of hypoxia-inducible factor-1? (HIF-1?). Under visible light irradiation, TiO2@[email protected] can elicit both Type I and Type II photodynamic effects, which causes lysosomal damage, HIF-1? gene silencing, and OSCC cell elimination efficiently. As a consequence of hypoxia relief and pyroptosis induction, TiO2@[email protected] reshapes the immune microenvironments by downregulation of key immunosuppressive factors, upregulation of immune cytokines, and activation of CD4+ and CD8+ T lymphocytes. Furthermore, patient-derived xenograft (PDX) and rat oral experimental carcinogenesis models prove that TiO2@[email protected]-mediated photodynamic therapy significantly inhibits the tumor growth and progression, and markedly enhances cancer immunity. In all, this study presents an effective hypoxia-adaptive photo-immunotherapeutic nanosystem with great potential for OSCC prevention and treatment.

» Author: Jia-Ying Zhou, Wen-Jin Wang, Chen-Yu Zhang, Yu-Yi Ling, Xiao-Jing Hong, Qiao Su, Wu-Guo Li, Zong-Wan Mao, Bin Cheng, Cai-Ping Tan, Tong Wu

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