In this section, you can access to the latest technical information related to the FUTURE project topic.

Hydrothermal Deposition of PCN?224 on 3D?Printed Porous ??Ca2SiO4 Scaffolds for Bone Regeneration

PCN?224 nanoparticles are deposited on the surface of 3D?printed porous ??Ca2SiO4 scaffolds by the hydrothermal method. The composite scaffolds possess uniform interconnected macropores (?400??m), with increased porosity and slower degradation. Deposition of PCN?224 significantly promotes rat bone marrow mesenchymal stem cell proliferation and the expression of osteogenesis?related genes. More importantly, the composite scaffolds significantly improve calvarial defect healing in rats, compared with ??Ca2SiO4 scaffolds.3D?printed bioceramics derived from silicone resin are of great interest in bone tissue engineering owing to their simple processes and low cost. Herein, PCN?224, as a subclass of metal?organic frameworks (MOFs), is successfully fabricated and deposited on the surface of 3D?printed porous ??Ca2SiO4 (C2S) scaffolds. The composite scaffolds possess uniform interconnected macropores (?400??m), with increased porosity and slower degradation. The results indicate that deposition of PCN?224 significantly promotes cell proliferation and the expression of osteogenesis?related genes. Moreover, the composite scaffolds significantly improve calvarial defect healing in rats, compared with C2S scaffolds. Therefore, the PCN?224?modified 3D?printed porous C2S composite scaffolds are promising candidates for bone tissue engineering.

» Author: Jianhang Du, Weiye Liu, Zhanrong Kang, Bin Yu, Dejian Li, Huifeng Ding, Jianming Huang

» Publication Date: 22/01/2022

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