In this section, you can access to the latest technical information related to the FUTURE project topic.

8-Hydroxyquinolin-2(1H)-one analogues as potential ?2-agonists: Design, synthesis and activity study

?2-Agonists that bind to plasmalemmal ?2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their ?2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50?

» Author: Gang Xing, Zhengxing Zhi, Ce Yi, Jitian Zou, Xuefeng Jing, Anthony Yiu-Ho Woo, Bin Lin, Li Pan, Yuyang Zhang, Maosheng Cheng

» Publication Date: 15/11/2021

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