In this section, you can access to the latest technical information related to the FUTURE project topic.

Multifunctional chitin-based barrier membrane with antibacterial and osteogenic activities for the treatment of periodontal disease

The guided tissue regeneration technique is an effective approach to repair periodontal defect. However, collagen barrier membranes used clinically lose stability easily, leading to soft tissue invasion, surgical site infection, and failure of osteogenesis. An ideal barrier membrane should possess proper antibacterial, osteoconductive activities, and favorable biodegradation. In this study, zinc oxide nanoparticles were homogeneously incorporated into the chitin hydrogel (ChT-1%ZnO) through one-step dissolution and regeneration method from alkaline/urea solution the first time. The remaining weights of ChT-1%ZnO in 150??g/mL lysozyme solution was 52% after 5?weeks soaking. ChT-1%ZnO showed statistical antibacterial activities for P. gingivalis and S. aureus at 6?h, 12?h, and 24?h. Moreover, ChT-1%ZnO exhibits osteogenesis promotion in vitro, and it was further evaluated with rat periodontal defect model in vivo. The cemento-enamel junction value in ChT-1%ZnO group is 1.608?mm, presenting a statistical difference compared with no-membrane (1.825?mm) and ChT group (1.685?mm) after 8?weeks postoperatively.

» Author: Tao Wu, Lin Huang, Jing Sun, Jiahui Sun, Qi Yan, Bo Duan, Lina Zhang, Bin Shi

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