In this section, you can access to the latest technical information related to the FUTURE project topic.

Synthesis and Chelation Study of a Fluoroionophore and a Glycopeptide based on an Aza Crown Iminosugar Structure

Capitalizing on a recently reported iminosugar-based aza-crown (ISAC) accessed by a double Staudinger azaWittig coupling reaction, we have expanded the structural diversity of this new family of sweet cyclam analogs. Replacement of the two secondary amines linking the iminosugar units by two amide bonds obtained a cyclodimerization with BOP and DIPEA led to a macrocycle that did not demonstrate efficient Zn2+ chelation unlike the parent ISAC. Introduction of two pyrene moieties on the secondary amines of the parent ISAC yielded a new fluoroionophore that selectively binds Hg2+ in methanol.

» Author: Alexandra Bordes, Ana Poveda, Nathalie Fontelle, Ana Ard?, J?r?me Guillard, Yi Bin Ruan, J?r?me Marrot, Shuki Imaeda, Atsushi Kato, J?r?me D?sir?, Juan Xie, Jes?s Jim?nez-Barbero, Yves Bl?riot

» Publication Date: 10/02/2021

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