In this section, you can access to the latest technical information related to the FUTURE project topic.

Airborne particulate matter (PM2.5) triggers cornea inflammation and pyroptosis via NLRP3 activation

Although studies have demonstrated that fine particulate matter (PM2.5) induces ocular surface damage, PM2.5 exposure causes cornea toxicity is not entirely clear. The aim of this study is to investigate the role of the nod-like receptor family pyrin domain containing three (NLRP3) inflammasome-mediated pyroptosis in PM2.5-related corneal toxicity. Human corneal epithelial cells (HCECs) were exposed to different concentrations of PM2.5, and the cell viability, expressions of NLRP3 inflammasome mediated pyroptosis axis molecules and intracellular reactive oxygen species (ROS) formation were measured in HCECs. Animal experiments were undertaken to topically apply PM2.5 suspension to mouse eyes for three months and the pyroptosis related molecules in the mouse corneas were measured.

» Author: Liangliang Niu, Liping Li, Chao Xing, Bin Luo, Chunchun Hu, Maomao Song, Jingping Niu, Ye Ruan, Xinghuai Sun, Yuan Lei

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