In this section, you can access to the latest technical information related to the FUTURE project topic.

Heavy metals exposure, lipid peroxidation and heart rate variability alteration: Association and mediation analyses in urban adults

Exposure to heavy metals was reported to be associated with heart rate variability (HRV) alteration. However, possible pathway of such association remains unclear. In this research, we investigated the possible role of lipid peroxidation in the associations between urinary heavy metals and HRV. We performed a cross-sectional study using baseline data of Wuhan-Zhuhai cohort. Urinary heavy metals (including lead, barium, antimony, cadmium, zinc, copper, iron and manganese), urinary 8-iso-prostaglandin-F2? levels (common biomarker for lipid peroxidation) and HRV indices (SDNN, r-MSSD, low frequency, high frequency and total power) were measured among 3022 participants. We conducted multivariable linear regression models to quantify associations between urinary 8-iso-prostaglandin-F2? (8-iso-PGF2?) and heavy metals or HRV indices. The potential role of 8-iso-PGF2? in the association of urinary heavy metals with HRV was evaluated through mediation analyses. After adjusting for potential confounders, urinary manganese, iron, copper, zinc, cadmium, antimony and barium were identified to be negatively associated with one or more HRV parameters. Each one-unit growth of log-transformed levels of urinary manganese, iron, copper, zinc, antimony and barium was associated with a 1.9%, 1.5%, 4.7%, 4.0%, 2.7% and 1.3% decrease in SDNN, respectively. We observed positive dose-response relationships between all eight urinary heavy metals and 8-iso-PGF2?, as well as negative association of urinary 8-iso-PGF2? with SDNN and total power (all P trend

» Author: Qiyou Tan, Jixuan Ma, Min Zhou, Dongming Wang, Bin Wang, Xiuquan Nie, Ge Mu, Xiaomin Zhang, Weihong Chen

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