In this section, you can access to the latest technical information related to the FUTURE project topic.

Sprayable agarose-derived dopamine-grafted microgels for promoting tissue adhesion in skin regeneration

A sprayable wound dressing is convenient, simple and easy to administer by nonmedical personnel in clinical medicine. In this study, agarose was employed for the first time as a spray for wound care. The strong gelling properties and cross-linked network structure of agarose makes it unsuitable for spraying. Furthermore, agarose gel exhibits shrinkage and is resistant to degradation. These features constitute major disadvantages of agarose as a wound dressing. To overcome these problems, we degraded and modified agarose using the 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) oxidation method, prepared degraded carboxylated agarose (Ag-CA) to improve the biodegradability, and developed a microgel structure that is easy to spray. In addition, we grafted dopamine onto Ag-CA (to yield Ag-g-DA) and evaluated its adhesion to cells and wounds. The surface topography, cell adhesion, tissue adhesion and protein release capabilities of the materials were evaluated, and a histological analysis was performed at 1, 2, 3, and 4?weeks. The introduction of carboxyl and catechol functional groups enabled agarose to bind to cells and thereby promote cell adhesion and growth. The wound adhesion and repair due to Ag-CA and Ag-g-DA were superior to those of unmodified agarose. Furthermore, the agarose-derived hydrogels promoted the downregulation of proinflammatory cytokines, suggesting a potential direction for research in skin regeneration and repair.

» Author: Bin Chu, Chaoxi Wu, Shunqing Tang, Mei Tu

» Publication Date: 01/09/2020

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