In this section, you can access to the latest technical information related to the FUTURE project topic.

Zinc-loaded palygorskite nanocomposites for catheter coating with excellent antibacterial and anti-biofilm properties

Catheter-associated urinary tract infections are the most common health care-associated infection in worldwide hospitals, which exacerbates the antibacterial resistance and the morbidity. The antibacterial materials composed of Zn(OH)2 and palygorskite were prepared by co-precipitation method for antibacterial coating of catheter in this study. The changes of surface morphology of catheter before and after coating confirmed that the antibacterial materials have been successfully coated on the catheter surface. This coating presented excellent antibacterial properties and a significant inhibitory effect on Escherichia coli and Staphylococcus aureus for at least seven days. Furthermore, it also exhibited a stronger ability to resist the formation of biofilm than the untreated catheters, and the biocompatibility to human bladder epithelial immortalized cells and the toxicity to human erythrocytes also were within acceptable limits. Therefore, this study is expected to provide a feasible and facile strategy to improve the antibacterial performance and biocompatibility of the untreated catheter preventing from bacterial resistance and catheter-associated urinary tract infections.

» Author: Yanmei Jing, Bin Mu, Mingming Zhang, Lu Wang, Huoqing Zhong, Xinyue Liu, Aiqin Wang

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