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Structural characterization and? ??glucosidase inhibitory and antioxidant activities of?fucoidans extracted from?Saccharina japonica

Two sulfated fucoidan fractions (Lj3 and Lj5) were extracted from Saccharina japonica and then subjected to acid hydrolysis to obtain Lj3h and Lj5h. Lj3h and Lj5h were characterized using IR, methylation analysis, and mass spectrometry. It was found that Lj3h and Lj5h were homogeneous low molecular weight fucoidans. Specifically, Lj3h was composed of the main chain of 1,3?linked ??L?fucopyranose residues with sulfate at C?2 and/or C?4 and three different monosaccharides (galactose, glucose, mannose) branched at C?2 and/or C?4 of fucose residue. Lj5h contained backbones of alternating galactopyranose residues and fucopyranose residues attached via a 1?3 linkage (galactofucan) and 1?6 linked galactan. The sulfation pattern was mainly located at C2/C4 fucose or galactose residues and more branches occupied in C?4 of fucose residue and C?2, C?3 or/and C?6 of galactose residue. In vitro assay indicated among the four fucoidans tested, only Lj5 showed potent ??glucosidase inhibitory activity with IC50 of 153.27 ? 22.89 ?g/mL, and the two parent fucoidans, Lj3 and Lj5, showed better antioxidant activity than their derivatives. These findings highlight the structure and bioactivity diversity of Saccharina japonica?derived fucoidans.

» Author: Songze Ke, Bin Wei, Taoshun Zhou, Wenhui Qiu, Sijia Wang, Jun Chen, Jianwei Chen, Huawei Zhang, Weihua Jin, Hong Wang

» Reference: doi:10.1002/cbdv.202000233

» Publication Date: 09/05/2020

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