In this section, you can access to the latest technical information related to the FUTURE project topic.

PB@PDA@Ag nanosystem for synergistically eradicating MRSA and accelerating diabetic wound healing assisted with laser irradiation

The ever-growing threats of multidrug-resistant bacterial infection and chronic wound healing have created an imperative need for the development of novel antibacterial materials and therapeutic strategies, especially for diabetic patients infected with multidrug-resistant bacteria. In this work, the nanocomplexes named as [email protected]@Ag were used for eradicating multidrug-resistant bacteria and accelerating wound healing of MRSA-infected diabetic model with the assistance of laser irradiation. In vitro results revealed that the combinational strategy exerted a synergistic effect for anti-MRSA through disrupting cell integrity, producing ROS, declining ATP, and oxidizing GSH, comparing with [email protected]@Ag or NIR laser irradiation alone. Moreover, in vivo assay demonstrated that this system effectively accelerated MRSA-infected diabetic wound healing by mitigating local inflammatory response and up-regulating VEGF expression on the wound bed. Meanwhile, satisfactory biocompatibility and negligible damage to major organs were observed. Altogether, the aforementioned results indicate that the combinational therapy of [email protected]@Ag and NIR irradiation shows a great potential application in the field of clinic infection.

» Author: Chunyi Tong, Xianghua Zhong, Yuejun Yang, Xu Liu, Guowei Zhong, Chang Xiao, Bin Liu, Wei Wang, Xiaoping Yang

» Reference: 10.1016/j.biomaterials.2020.119936

» Publication Date: 01/06/2020

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