An implantable and wirelessly charged nitric oxide (NO)?release device (NO?wLED) capable of being remote?controlled is constructed to overcome the issue in that it is difficult to treat deep cancer by phototherapy due to the insufficient penetration capability of light. With irradiation in the body and the good tissue penetration of NO, suppression of orthotopic and postsurgery cancers is achieved.Traditional phototherapies face the issue that the insufficient penetration of light means it is difficult to reach deep lesions, which greatly reduces the feasibility of cancer therapy. Here, an implantable nitric oxide (NO)?release device is developed to achieve long?term, long?distance, remote?controllable gas therapy for cancer. The device consists of a wirelessly powered light?emitting diode (wLED) and S?nitrosoglutathione encapsulated with poly(dimethylsiloxane) (PDMS), obtaining the NO?release wLED (NO?wLED). It is found that NO release from the NO?wLED can be triggered by wireless charging and the concentration of produced NO reaches 0.43 ? 10?6 m min?1, which can achieve a killing effect on cancer cells. In vivo anticancer experiments exhibit obvious inhibitory effect on the growth of orthotopic cancer when the implanted NO?wLED is irradiated by wireless charging. In addition, recurrence of cancer can be prevented by NO produced from the NO?wLED after surgery. By illumination in the body, this strategy overcomes the poor penetration and long?wavelength dependence of traditional phototherapies, which also provides a promising approach for in vivo gas therapy remote?controlled by wireless charging.

» Author: Bin Li, Ping Ji, Si?Yuan Peng, Pei Pan, Di?Wei Zheng, Chu?Xin Li, Yun?Xia Sun, Xian?Zheng Zhang

» Reference: doi:10.1002/adma.202000376

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