In this section, you can access to the latest technical information related to the FUTURE project topic.

Biodegradable Nanoprodrugs: ?Delivering? ROS to Cancer Cells for Molecular Dynamic Therapy

Biodegradable nanoprodrugs of transferrin?modified MgO2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy. The nanosheets favor acidic conditions and low catalase activity in the tumor microenvironment to react with protons and release nontoxic Mg2+. This reaction simultaneously produces abundant H2O2 and highly toxic ?OH, which destroys tumor cells.Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming the inevitable drawback of side effects on normal tissues, hold promise as next?generation cancer therapy candidates. Biodegradable nanoprodrugs of transferrin?modified MgO2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy. The nanosheets favor the acidic and low catalase activity tumor microenvironment to react with proton and release nontoxic Mg2+. This reaction simultaneously produces abundant H2O2 to induce cell death and damage the structure of transferrin to release Fe3+, which will react with H2O2 to produce highly toxic ?OH to kill tumor cells.

» Author: Zhong?min Tang, Yan?yan Liu, Da?long Ni, Jia?jia Zhou, Meng Zhang, Pei?ran Zhao, Bin Lv, Han Wang, Da?yong Jin, Wen?bo Bu

» Reference: doi:10.1002/adma.201904011

» Publication Date: 03/12/2019

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