In this section, you can access to the latest technical information related to the FUTURE project topic.

Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors

A series of new triazole fused imidazo[2,1-b]thiazole hybrids (9a?u) were designed, synthesized and evaluated as antimicrobial agents. Compounds 9c, 9d, 9e, 9j and 9l showed promising broad spectrum antimicrobial activity. Further, compound 9c exhibited significant anti-biofilm activity with single and mixed biofilm disruption demonstrated by Field Emission Scanning Electron Microscope (FE-SEM). Furthermore, molecular docking studies revealed that they interact with the virulence factor, Staphylococcus aureus dehydrosqualene synthase (CrtM) (PDB ID: 2ZCS). Overall, the findings suggest compound 9c as potential lead for further development of novel antibacterial and anti-biofilm agents.

» Author: Mohd Adil Shareef, Kanugala Sirisha, Ibrahim Bin Sayeed, Irfan Khan, Thipparapu Ganapathi, Syed Akbar, C. Ganesh Kumar, Ahmed Kamal, Bathini Nagendra Babu

» Publication Date: 12/08/2019

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