In this section, you can access to the latest technical information related to the FUTURE project topic.

Precise Deciphering of Brain Vasculatures and Microscopic Tumors with Dual NIR?II Fluorescence and Photoacoustic Imaging

Uniform conjugated polymer nanoparticles with dual NIR?II absorption and emission, good photostability, and excellent biocompatibility are used to facilitate NIR?II fluorescence imaging of brain vasculatures and NIR?II photoacoustic imaging of orthotopic deep microscopic tumors with the assistance of focused ultrasound. The synergetic dual NIR?II imaging demonstrates outstanding properties, including deep penetration, high spatiotemporal resolution, and large signal to background ratio in brain imaging.Diagnostics of cerebrovascular structures and microscopic tumors with intact blood?brain barrier (BBB) significantly contributes to timely treatment of patients bearing neurological diseases. Dual NIR?II fluorescence and photoacoustic imaging (PAI) is expected to offer powerful strength, including good spatiotemporal resolution, deep penetration, and large signal?to?background ratio (SBR) for precise brain diagnostics. Herein, biocompatible and photostable conjugated polymer nanoparticles (CP NPs) are reported for dual?modality brain imaging in the NIR?II window. Uniform CP NPs with a size of 50 nm are fabricated from microfluidics devices, which show an emission peak at 1156 nm with a large absorptivity of 35.2 L g?1 cm?1 at 1000 nm. The NIR?II fluorescence imaging resolves hemodynamics and cerebral vasculatures with a spatial resolution of 23 ?m at a depth of 600 ?m. The NIR?II PAI enables successful noninvasive mapping of deep microscopic brain tumors (

» Author: Bing Guo, Zhe Feng, Dehong Hu, Shidang Xu, Eshu Middha, Yutong Pan, Chengbo Liu, Hairong Zheng, Jun Qian, Zonghai Sheng, Bin Liu

» Reference: doi:10.1002/adma.201902504

» Publication Date: 23/07/2019

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