In this section, you can access to the latest technical information related to the FUTURE project topic.

Tandem activated photodynamic and chemotherapy: Using pH-Sensitive nanosystems to realize different tumour distributions of photosensitizer/prodrug for amplified combination therapy

Photodynamic therapy (PDT) combined with hypoxia-activated prodrugs to overcome hypoxia environment has been recently explored as a promising clinical modality for cancer therapy. Nevertheless, delivering these two therapeutic agents together to different tumour areas that possess a number of biological barriers remains a considerable challenge. Herein, we used the semiconducting polyelectrolyte-based zwitterionic photosensitizer (PFNS) to modify the surface of upconversion nanoparticles (NPs) and prepare near-infrared (NIR) light-responsive PDT agents ([email protected]). A pH-sensitive Mn-Ca3(PO4)2 (MnCaP) layer was further coated onto [email protected] with the hypoxia-activated prodrug AQ4N incorporated inside. The final nanocomposites exhibited a diameter of 73?nm with high stability in the blood and a remarkably enhanced permeability and retention (EPR) effect in tumours. Importantly, when these nanoparticles reached the tumour site, the acidic tumour microenvironment (pH 6.5?6.8) decomposed the MnCaP layer, releasing both [email protected] (30?nm) and AQ4N. The relatively small size of [email protected] and AQ4N satisfied the different distribution requirements in tumour and achieved a high therapeutic effect, thereby reaching an inhibition rate of as high as 83%. In addition, Mn2+ ions can be released during the decomposition of CaP, leading to a significantly increased magnetic resonance (MR) signal in the tumour site. Overall, we report a nanoparticle guided by MRI and fluorescence imaging possesses of tandem active pattern of PDT and chemotherapy, which is promising for future clinical diagnosis and treatment.

» Author: Yu Ji, Lu Feng, Wenbo Hu, Hui Zhao, Yufu Tang, Bin Liu, Xiaoming Hu, Xiang Li, Xiaomei Lu, Quli Fan, Wei Huang

» Reference: 10.1016/j.biomaterials.2019.119393

» Publication Date: 27/07/2019

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