In this section, you can access to the latest technical information related to the FUTURE project topic.

Polymeric Nanoparticles Responsive to Intracellular ROS for Anticancer Drug Delivery

Thioketal and thioether are moieties used to fabricate reactive oxygen species (ROS)-responsive polymers for drug delivery. In this paper, three amphiphilic copolymers of mPEG-poly(ester-thioether), mPEG-poly(thioketal-ester) and mPEG-poly(thioketal-ester-thioether) were synthesized. The ROS-responsive behaviors of the three copolymers nanoparticles as drug carriers were investigated. The ROS-sensitivity was demonstrated by NMR, DLS, and SEM. mPEG-poly(ester-thioether) nanoparticles exhibited the fastest drug release rate, which possessed the best ROS sensitivity. The in vitro anticancer activity of the DOX-loaded nanoparticles was studied, the results revealed that the mPEG-poly(ester-thioether) nanoparticles showed the most efficient anticancer activity. Notably, all the three ROS-responsive copolymers nanoparticles showed enhanced cellular uptake and anticancer efficacy comparing to the control mPEG-b-PCL nanoparticles.

» Author: Long Xu, Mingying Zhao, Wenxia Gao, Yidi Yang, Jianfeng Zhang, Yuji Pu, Bin He

» Reference: 10.1016/j.colsurfb.2019.05.064

» Publication Date: 25/05/2019

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