In this section, you can access to the latest technical information related to the FUTURE project topic.

Complement inhibition ameliorates blast-induced acute lung injury in rats: Potential role of complement in intracellular HMGB1-mediated inflammation

AbstractBackground and objective

Complement activation as an early and important inflammatory process contributes to multiple organ dysfunction after trauma. We have recently shown that complement inhibition by decay-accelerating factor (DAF) protects brain from blast-overpressure (BOP)-induced damage. This study was conducted to determine the effect of DAF on acute lung injury induced by BOP exposure and to elucidate its possible mechanisms of action.

» Author: Yansong Li,  Zhangsheng Yang,  Mikulas Chavko,  Bin Liu,  Olawale A. Aderemi,  Milomir O. Simovic,  Michael A. Dubick,  Leopoldo C. Cancio

» Reference: https://doi.org/10.1371/journal.pone.0202594

» Publication Date: 22/08/2018

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