In this section, you can access to the latest technical information related to the FUTURE project topic.

Polymer blend nanofibers containing polycaprolactone as biocompatible and biodegradable binding agent to fabricate electrospun three-dimensional scaffolds/structures

To develop tissue engineering scaffolds that possess similar morphological structures to natural extracellular matrices (ECMs) is a major technological challenge. Herein, the feasibility of utilizing polycaprolactone (PCL) as biocompatible and biodegradable binding agent to fabricate electrospun three-dimensional (3D) scaffolds has been demonstrated. The obtained 3D scaffolds are soft while elastic, and they possess interconnected and hierarchically structured pores with sizes in the range from sub-microns to hundreds of microns; hence, they are morphologically similar to natural ECMs thus well suited for cell functions and tissue formation. It is envisioned that various thermoplastic polymers could be fabricated into 3D nanofibrous scaffolds/structures by first making blend nanofibers with PCL followed by processing via the thermally induced (nanofiber) self-agglomeration (TISA) method and finally being thermally stabilized, and the resulting electrospun 3D nanofibrous scaffolds/structures might to be useful for a variety of applications (particularly those related to tissue engineering).

» Author: Tao Xu, Zhipeng Liang, Bin Ding, Quan Feng, Hao Fong

» Reference: 10.1016/j.polymer.2018.07.074

» Publication Date: 30/07/2018

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