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Two New Chromone Glycosides from Roots of Saposhnikovia divaricata

Five chromone glycosides were isolated from water?soluable portions of 70% EtOH extract of roots of Saposhnikovia divaricata, including two new chromone glycosides 1 and 2. The structures of the chromone glycosides were identified as (3?S)?3??O???D?apiofuranosyl?(1 ? 6)?O???D?glucopyranosylhamaudol (1), (2?S)? 4??O???D?apiofuranosyl?(1 ? 6)?O???D?glucopyranosylvisamminol (2), sec?O?glucosylhamaudol (3), 4??O???D?glucopyranosylvisamminol (4), and 4??O???D?glucopyranosyl?5?O?methylvisamminol (5) on the basis of extensive spectroscopic methods, and the absolute configurations of the new compounds were elucidated by the electronic circular dichroism (ECD) calculation and acid hydrolysis. The cytotoxic activities of the glycosides 1 ? 5 against three human cancer cell lines (PC?3, SK?OV?3, and H460) were evaluated. The result showed the compounds 1 – 5 had weak cytotoxic activities against the human cancer cell lines with IC50 values in the range of 48.54 ± 0.80 – 94.25 ± 1.45 ?M.This article is protected by copyright. All rights reserved.

» Author: Si?Yuan Ma , Ling?Gao Shi , Zheng?Bing Gu , Yu?Lan Wu , Liu?Bin Wei , Qi?Qiu Wei , Xing?Ling Gao , Na Liao

» Reference: doi:10.1002/cbdv.201800253

» Publication Date: 10/07/2018

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