In this section, you can access to the latest technical information related to the FUTURE project topic.

Hypofolins A – L, ent?Labdane Diterpenoids from the Roots of Hypoestes phyllostachya ‘Pink Splash’

Twelve new ent?labdane diterpenoids, hypofolins A – F (1 – 6) and hypofolins G – L (7a/7b, 8a/8b, and 9a/9b), were isolated from the roots of Hypoestes phyllostachya ‘Pink Splash’. Their structures were elucidated by extensive 1D? and 2D?NMR spectroscopic and HR?MS data. The absolute configurations of 1, 2, 5, and 7a/7b were determined by single crystal X?ray diffraction and ECD analysis, as well as chemical transformations. Compounds 7a/7b, 8a/8b, and 9a/9b were isolated as three pairs of interconverting mixture of two isomers between ketone and hemiketal types. Compound 1 showed weak cytotoxicity against SMMC?7721 cell line with IC50 value of 31.40 ?m.

» Author: Bin Cheng , Lin?Fen Ding , Tong Yan , Zhang?Qiao Xie , Zhi?jun Zhang , Liu?Dong Song , Xing?De Wu , Qin?Shi Zhao

» Reference: doi:10.1002/cbdv.201800124

» Publication Date: 21/05/2018

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