In this section, you can access to the latest technical information related to the FUTURE project topic.

Discovery of dihydrobenzofuran neolignans from Rubus ideaus L. with enantioselective anti-A?1–42 aggregation activity

Four new dihydrobenzofuran neolignans 1a/1b and 2a/2b were isolated from the fruit of Rubus ideaus. 1a/1b and 2a/2b as two pairs of enantiomers were separated on a chiral chromatographic column. Their structures were determined using a suite of techniques including 1D and 2D NMR, HRESIMS, together with theoretical electronic circular dichroism (ECD) calculation. All compounds were evaluated for their inhibition of self-induced A? 1–42 aggregation. Compounds 1b and 2a exhibited optimal A? 1–42 aggregation inhibition capability, with an inhibition potency of 81.6% and 83.4% at 20??M, respectively. Additionally, molecular docking was performed to identify the possible factor responsible for the enantioselectivity in the anti-A? 1–42 aggregation activity.

» Author: Le Zhou, Jie Wang, Rui Guo, Bin Lin, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song

» Reference: Bioorganic Chemistry, Volume 80

» Publication Date: 01/10/2018

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