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In this section, you can access to the latest technical information related to the FUTURE project topic.
Trimethylsilyloxide‐Catalysed Peterson Olefinations with 2,2‐Bis(trimethylsilyl)‐1,3‐dithiane (pages 7259–7263)
The synthesis of the reagent 2,2‐bis(trimethylsilyl)‐1,3‐dithiane was directly achieved in an excellent yield from 1,3‐dithiane in one step. The bench‐stable reagent can be utilized for Peterson olefinations using either TMSOK/Bu4NCl or fluoride ion as promoter of α‐silyl carbanion formation, thereby generating ketene dithioacetals, which are versatile intermediates in organic synthesis. Olefination reactions were successfully achieved with aromatic, heteroaromatic, aliphatic aldehydes and ketones.
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» Author: Atul Manvar andDonal F. O'Shea*
» Reference: European Journal of Organic ChemistryVolume 2015, Issue 33, pages 7259–7263, November 2015
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