In this section, you can access to the latest technical information related to the FUTURE project topic.

Photo-induced reductive cross-coupling of aldehydes, ketones and imines with electron-deficient arenes to construct aryl substituted alcohols and amines

Umpolung reactions of C=X bonds (X = O, N) are valuable ways of constructing new C–C bonds, which are sometimes difficult to be constructed using traditional synthetic pathways. Classical polarity inversion of C=X bonds (X = O, N) usually requires air or moisture-sensitive and strong reducing agents, which limit the feasibility of substrate scope. Herein we describe a photo-induced reductive cross-coupling reaction of aldehydes, ketones and imines with electron-deficient arenes (aromatic nitriles) using fac-Ir(ppy)3 as a photocatalyst and diisopropylethylamine (DIPEA) as a terminal reductant under visible light irradiation. Mild conditions and high yields mean that this new polarity inversion strategy can be used with aryl-substituted alcohols and amines. Spectroscopic studies and control experiments have demonstrated the oxidative quenching of Ir(ppy)3 * by electron-deficient arenes involved in the key step for the C–C bond formation.

» Author: Zan Liu, Xiaolei Nan, Tao Lei, Chao Zhou, Yang Wang, Wenqiang Liu, Bin Chen, Chenho Tung, Lizhu Wu

» Reference: Chinese Journal of Catalysis, Volume 39, Issue 3

» Publication Date: 01/03/2018

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