In this section, you can access to the latest technical information related to the FUTURE project topic.

Diurnal changes of glycogen molecular structure in healthy and diabetic mice

Glycogen is a complex branched glucose polymer functioning as a blood-sugar reservoir in animals. Liver glycogen ? particles can bind together to form ? particles, which have a slower enzymatic degradation to glucose. The linkage between ? particles in ? particles in diabetic liver breaks (is fragile) in dimethyl sulfoxide (DMSO), a H-bond disruptor, consistent with blood-sugar homeostasis loss in diabetes. We examined diurnal changes in the molecular structure of healthy and diabetic mouse-liver glycogen. Healthy mouse glycogen was fragile to DMSO during glycogen synthesis but not degradation; diabetic glycogen was always fragile. Two alternative mechanisms for this are suggested: healthy glycogen is fragile when formed and becomes stable during subsequent degradation, a process damaged in diabetes; alternatively, there are two types of glycogen: one compact but fragile and the other loose but non-fragile. This suggests potential types of diabetes drug targets through modifying the activities of glycogen synthesis enzymes.

» Author: Zhenxia Hu, Bin Deng, Xinle Tan, Hua Gan, Cheng Li, Sharif S. Nada, Mitchell A. Sullivan, Jialun Li, Xiaoyin Jiang, Enpeng Li, Robert G. Gilbert

» Reference: Carbohydrate Polymers, Volume 185

» Publication Date: 01/04/2018

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