In this section, you can access to the latest technical information related to the FUTURE project topic.

Development of a Series of Novel o-Phenylenediamine-based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

A novel series of o-phenylenediamine-based inhibitors of indoleamine 2,3-dioxygenase (IDO) has been identified. IDO is a heme-containing enzyme, overexpressed in the tumor microenvironment of many cancers, which can contribute to the suppression of the host immune system. Synthetic modifications to a previously described diarylether series resulted in an additional degree of molecular diversity which was exploited to afford compounds that demonstrated significant potency in the HeLa human cervical cancer IDO1 assay.

» Author: David K. Williams, Jay A. Markwalder, Aaron J. Balog, Bin Chen, Libing Chen, Jennifer Donnell, Lauren Haque, Amy C. Hart, Sunil K. Mandal, Andrew Nation, Weifang Shan, Gregory D. Vite, Kelly Covello, John T. Hunt, Maria N. J

» Reference: Bioorganic & Medicinal Chemistry Letters

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