In this section, you can access to the latest technical information related to the FUTURE project topic.

Discovery of highly potent, selective, covalent inhibitors of JAK3

A useful and novel set of tool molecules have been identified which bind irreversibly to the JAK3 active site cysteine residue. The design was based on crystal structure information and a comparative study of several electrophilic warheads.

» Author: James Kempson, Damaso Ovalle, Junqing Guo, Stephen T. Wrobleski, Shuqun Lin, Steven H. Spergel, James J.-W. Duan, Bin Jiang, Zhonghui Lu, Jagabandhu Das, Bingwei V. Yang, John Hynes, Hong Wu, John Tokarski, John S. Sack, Jav

» Reference: Bioorganic & Medicinal Chemistry Letters, Volume 27, Issue 20

» Publication Date: 15/10/2017

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