In this section, you can access to the latest technical information related to the FUTURE project topic.

Structure and genetics of the O-specific polysaccharide of Escherichia coli O27

The O-specific polysaccharide (O-antigen) is a part of the lipopolysaccharide on the cell surface of gram-negative bacteria. The O-polysaccharide was obtained by mild acid hydrolysis of the lipopolysaccharide of Escherichia coli O27 and studied by sugar analysis and Smith degradation along with 1H and 13C NMR spectroscopy. The following structure of the branched hexasaccharide repeating unit was established, which is unique among known structures of bacterial polysaccharides: Image 2 where GlcA is non-stoichiometrically O-acetylated at position 3 (?22%) or 4 (?37%). Functions of genes in the O-antigen gene cluster of E. coli O27 were tentatively assigned by comparison ith sequences in the available databases and found to be consistent with the O-polysaccharide structure.

» Author: Andrei V. Perepelov, Tingting Chen, Sofya N. Senchenkova, Andrei V. Filatov, Jingjie Song, Alexander S. Shashkov, Bin Liu, Yuriy A. Knirel

» Reference: Carbohydrate Research

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