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In this section, you can access to the latest technical information related to the FUTURE project topic.
Design, synthesis and biological activity of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides as new antitubercular agents
A series of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides (IPAs), based on the structure of WZY02 discovered in our lab, were designed and synthesized as new anti-TB agents. Results reveal that many of them exhibit excellent in vitro inhibitory activity with low nanomolar MIC values against both drug-sensitive MTB strain H37Rv and drug-resistant clinical isolates. Compounds 15b and 15d display good safety and pharmacokinetic profiles, suggesting their promising potential to be lead compounds for future antitubercular drug discovery.
» Author: Wang Apeng, Kai Lv, Linhu Li, Hongtao Liu, Zeyu Tao, Bin Wang, Mingliang Liu, Chao Ma, Xican Ma, Bing Han, Aoyu Wang, Yu Lu
» Reference: 10.1016/j.ejmech.2019.06.038
» Publication Date: 14/06/2019
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