In this section, you can access to the latest technical information related to the FUTURE project topic.

Synthesis and characterization of simple and binary drug delivery systems for sustainable release of ciprofloxacin

AbstractBiopolymers are widely used for design sustained drug delivery systems (SDDS) and biomaterials for tissue engineering. Reducing wound infections still constitutes one of the major challenges facing the wound care. The aim of this study was to synthetize, characterize and evaluate a single (polymeric spheres) and a binary polymeric biomaterial (polymeric spheres imbedded in a poly(vinyl alcohol) (PVA) scaffold) as a SDDS. Polymeric spheres were prepared by complex coacervation and the binary system of the chitosan (CH) -PVA beads embedded in a PVA scaffold prepared by Ice Segregation Induced Self-Assembly (ISISA) process. Both systems were physicochemically characterized using Fourier Transform Infrared spectroscopy (FTIR), X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). In vitro ciprofloxacin (CFX) release kinetics were evaluated simulating physiological conditions under sink conditions. Physicochemical characterization showed interactions between all components forming beads; in contrast, beads-scaffold interactions were not detected making evident the presence of two different phases in the binary system. The CFX release kinetics revealed that both systems were SDDS, simple system release 97.0?±?6.9% in 7 days, while the binary was 68.56?±?6.6% during 14 days of evaluation. Binary system emerges as a potential tool for evaluate the long-lasting infection control in the treatment of skin wounds.Keywords: Chitosan, ciprofloxacin, drug delivery system, ISISA, poly(vinyl alcohol), scaffold Article Metrics Views 28 Citations Crossref 0 Web of Science 0 Scopus 0 Altmetric Article metrics information Disclaimer for citing articles Login options Log in OpenAthens Shibboleth Log in to Taylor & Francis Online Username Password Forgot password? Remember Me Log in .submit-login { display: none; } Shibboleth OpenAthens Restore content access Restore content access for purchases made as guest Purchase * Save for later Item saved, go to cart Online Article Purchase 24 hours access for EUR 43.00 Add to cart Article Purchase - Online Checkout * Local tax will be added as applicable var script = document.createElement('script'); script.type='text/javascript'; script.src='//s7.addthis.com/js/250/addthis_widget.js#pubid=xa-4faab26f2cff13a7'; script.async = true; $('head').append(script)   Browse journals by subject Back to top Area Studies Arts Behavioral Sciences Bioscience Built Environment Communication Studies Computer Science Development Studies Earth Sciences Economics, Finance, Business & Industry Education Engineering & Technology Environment & Agriculture Environment and Sustainability Food Science & Technology Geography Health and Social Care Humanities Information Science Language & Literature Law Mathematics & Statistics Medicine, Dentistry, Nursing & Allied Health Museum and Heritage Studies Physical Sciences Politics & International Relations Social Sciences Sports and Leisure Tourism, Hospitality and Events Urban Studies Information forAuthorsEditorsLibrariansSocieties Open accessOverviewOpen journalsOpen SelectCogent OA Help and infoHelpFAQsNewsroomContact usCommercial services Connect with Taylor & Francis Get the latest news and offers tailored to you.Sign me up Copyright © 2018 Informa UK LimitedPrivacy policy & cookiesTerms & conditionsAccessibilityRegistered in England & Wales No. 30990675 Howick Place | London | SW1P 1WG Accept We use cookies to improve your website experience. To learn about our use of cookies and how you can manage your cookie settings, please see our Cookie Policy. By closing this message, you are consenting to our use of cookies. (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-W2RHRDH');

» Author: Iraís A. Quintero-Ortega

» Publication Date: 31/12/2018

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